Barrett esophagus Radiology

Barrett Esophagus. Radiolog

Barrett oesophagus Radiology Reference Article

In this example, the Barrett esophagus is at the gastro-esophageal junction, but it can occur in patches anywhere from the mid-esophagus down to the gastro-esophageal junction Barrett esophagus is an acquired condition with progressive columnar metaplasia of the esophagus due to chronic reflux esophagitis. The premalignant nature of this entity is well recognized. However, radiologic diagnosis has been limited by the nonspecificity of findings associated with the condition

Zoomed-in images of the fine reticular pattern superimposed on oesophagitis (fine granular pattern) found in Barrett oesophagus. The area of fine reticulation is either circled in red or pointed to with red arrows Normal esophageal mucosa has a shiny, smooth, pink surface. (Right) Two views from an esophagram show a polypoid mass that represents an adenocarcinoma arising in Barrett mucosa. TERMINOLOG Barrett's esophagus. Barrett's esophagus (columnar metaplasia) is the result of long-standing reflux esophagitis. Most patients have reflux and a hiatus hernia. The diagnosis is strongly suggested by: Mid or high esophageal ulcer Mid or high esophageal web-like stricture Reticular mucosal pattern On the left a patient with a Barrett's esophagus Comment: Per 2016 ACG guidelines, the diagnosis of Barrett esophagus in this case is made owing to the presence of goblet cells, with the assumption that the biopsy is taken from distal esophagus and the mucosal irregularity extends to at least 1 cm above the top of the gastric folds Barrett's esophagus and Adenocarcinoma. Barrett's esophagus is a proven risk factor for the development of an adenocarcinoma. The incidence of cancer in Barrett's however is controversial. Who, how, and when individuals should be screened is unresolved. Adenocarcinoma was 10% of esophageal malignancies in 1960s

Barrett esophagus Radiology Case Radiopaedia

  1. The clinical and radiologic aspects of Barrett's esophagus are presented in Chapter 19 . Various types of columnar epithelium have been described in Barrett's esophagus, including a junctional-type epithelium, a gastric fundus-type epithelium, and an intestinal-type or specialized columnar epithelium
  2. Barrett's esophagus. Barrett's esophagus is an acquired condition in which there is progressive columnar metaplasia of the distal esophagus secondary to long-standing reflux disease. Barrett's esophagus is occasionally manifested by a single large ulcer within the columnar epithelium, occurring at a discrete distance from the.
  3. However, adenomas may develop in patients with Barrett's esophagus (see Chapter 19 ). These adenomas are important because of the risk of malignant degeneration via an adenoma-carcinoma sequence similar to that found in the colon. Esophageal adenomas should therefore be resected endoscopically or surgically, whenever feasible. Radiographic Finding
  4. ed; experts aren't certain how common Barrett esophagus is worldwide. 1,2 In the United States, applying general.
  5. What is the role of radiology in evaluating patients with Barrett's esophagus? M.Y.M. Chen, D.J. Ott (Winston-Salem) Barrett's esophagus is a well-recognized entity in which the normal squamous epithelium in the distal esophagus has been replaced by a columnar epithelial lining, presumably as a result of chronic reflux esophagitis [].Barrett's esophagus can be suggested endoscopically by the.

Barrett esophagus: reticular pattern of the mucosa

  1. Intestinal metaplasia of the esophagus redirects here. Barrett's esophagus, abbreviated BE, is a relatively common pathology of the esophagus, that is associated with an increased risk of esophageal adenocarcinoma
  2. Esophagus Esophageal Carcinoma Overview. Adenocarcinoma • Most common esophageal cancer in the United States • More common in the lower third of the esophagus. Squamous cell carcinoma • Most common esophageal cancer worldwide • More common in the upper third of the esophagus. Risk Factors. Tobacco use. Heavy alcohol use. Barrett.
  3. Barrett Esophagus., Radiology | DeepDyve. Barrett Esophagus. Barrett Esophagus. Margulis, A R; Shapiro, H A 1984-02-01 00:00:00 Alexander Howard R. Margulis, M.D. A. Shapiro, M.D. currence a new of gastroesophageal phenomenon; rather reflux its effects is Yet is an The authors take a conservative stand on the relationship of Barrett esophagus.
  4. Gastrointestinal manifestations of scleroderma are relatively common (40-45%), following skin changes and Raynaud's phenomena. In the GI tract, there may be atrophy of the smooth muscle. CD4 T cells are believed to play an important role in its pathogenesis. The esophagus is affected most frequently (85%) with lesser changes in the stomach.
  5. The frequency and characteristics of esophageal dysmotility in Sjögren's syndrome (SS) are as controversial as their related symptoms. We evaluated esophageal function and gastroesophageal reflux (GER) in 21 SS patients using manometry and 24-hr esophageal pH monitoring. All patients complained of x
  6. Barrett's Esophagus (BE) is a complication of chronic gastroesophageal reflux disease (GERD). The normal valve between the esophagus and stomach is incompetent and stomach fluid causes changes in the type of cells in the esophagus. pathology, pulmonary medicine and radiology. Virginia Litle, MD, Director, Barrett's Esophageal Program BE.
  7. Barrett esophagus is an acquired condition with progressive columnar metaplasia of the esophagus due to chronic reflux esophagitis. The premalignant nature of this entity is well recognized. However, radiologic diagnosis has been limited by the nonspecificity of findings associated with the conditio

Barrett esophagus is a well-recognized entity in which there is progressive columnar metaplasia of the lower esophagus due to longstanding gastroesophageal reflux and reflux esophagitis [1]. This condition is important because it is associated with an increased risk of developing esophageal adenocarcinoma by a well-established sequence from dysplasia to carcinoma [2] Barrett esophagus is a well-recognized entity in which there is progressive columnar metaplasia of the lower esophagus due to longstanding gastroesophageal reflux and reflux esophagitis [1] Barrett esophagus is an acquired condition characterized by columnar (intestinal) metaplasia of the distal esophagus secondary to chronic GER and reflux esophagitis . Barrett esophagus is more common than previously recognized, with an overall frequency of about 10% in patients with reflux esophagitis and 40% in patients with peptic strictures Barrett esophagus: update for radiologists Barrett esophagus: update for radiologists Levine, M. 2004-12-15 00:00:00 This arbitrary cutoff of 3 cm was used to eliminate false- Barrett esophagus is a well-recognized entity in which positive diagnoses of Barrett esophagus caused by diffi- there is progressive columnar metaplasia of the lower culty in identifying the precise anatomic location of.

Radiology. 1984 Feb;150(2):305-9. Adenocarcinoma of the esophagus: relationship to Barrett mucosa. Levine MS, Caroline D, Thompson JJ, Kressel HY, Laufer I, Herlinger H. Primary adenocarcinoma of the esophagus is thought to be a rare lesion. However, pathologic records at our institution from 1979 to 1982 show that adenocarcinoma accounted for. Barrett's esophagus with ulcerated (arrow) adenocarcinoma 85. 3-Lymphoma : -Because the esophagus and stomach do not normally have lymphocytes , primary lymphoma is rare unless present from inflammation -Secondary metastatic lymphoma is more common -Radiographic Features : as before 86 This article reviews our experience with 19 cases of Barrett oesophagus. Radiological findings included hiatus hernia, gastro-oesophageal reflux, strictures and oesophagitis. The strictures were most commonly distal. The recently described lace-like reticular pattern of the mucosa was noted in one case of the 15 who had air-contrast views Discussion: Barrett esophagus represents replacement of squamous epithelium of the esophagus by metaplastic columnar epithelium, secondary to chronic gastroesophageal reflux. These patients have a 40-fold higher risk than the general population in developing adenocarcinoma. Squamous cell carcinoma typically represents greater than 90% of esophageal cancers

Barrett oesophagus Radiology Case Radiopaedia

The association with Barrett's esophagus is further supported by the concomitant finding of esophageal adenocarcinoma in many patients. Isolated lesions without associated Barrett's smaller than 1 cm may be resected endoscopically using a biopsy forceps or snare. Lesions larger than 1 cm and those containing high-grade dysplasia can be removed. A recent increase in the number of Barrett's esophagis being diagnosed is probably directly related to a proportional increase in endoscopic biopsies of the esophagus and awareness of premalignant potential of Barrett's mucosa. While the endoscopist can detect Barrett's mucosa with fair degree of accuracy, the radiologic diagnosis of Barrett's esophagus still remains a diagnostic challenge. OESOPHAGUS AND STOMACH esophagus surveillance is superior to the standardized random biopsy protocol: results from a large cohort study. Gastrointest Endosc 2014:pii: S0016-5107(14)00105-9. 5 Fitzgerald RC, di Pietro M, Ragunath K, et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus

Barrett's esophagus, with midesoph ageal stricture (black arrows ) and delicate reticular pattern extending distally a moderate distance from stricture (approximately to level of whit e arrow). (From Levine MS, Kressel HY, Caroline DF, et aI: Barrett esophagus: Reticular pattern of the mucosa. Radiology 147:663-667, 1983; with permission. Barrett's (gastric-lined) esophagus. Radiology case of the month. Barrett's (gastric-lined) esophagus Nebr Med J. 1974 Sep;59(9):358-9. Author R K Harned. PMID: 4422866 No abstract available. MeSH terms Esophageal Stenosis / diagnostic imaging Esophagitis, Peptic / diagnostic imaging*. Subsequent review of the radiology database at our hospital revealed that 20 of the 142 patients with short-segment Barrett's esophagus had double-contrast studies (including 17 double-contrast upper gastrointestinal tract examinations and three double-contrast esophagrams) that had been performed within 1 year of endoscopy Carcinoma of the Esophagus. Two slightly different images of the distal esophagus from a barium swallow demonstrate an irregular, somewhat nodular filling defect (white arrows) stretching for a considerable part of the distal esophagus, narrowing the lumen. There is a shelf-like defect approximately where the tumor begins (red arrows) Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Barrett Esophagus. link. Bookmarks (0) Gastrointestinal. Diagnosis. Esophagus. Inflammation. Barrett Esophagus.

Barrett Esophagus Radiology Ke

Sharma Pet al. Development and validation of a classification system to identify highgrade dysplasia and esophageal adenocarcinoma in Barrett`s esophagus usingnarrow band imaging, Gastroenterology 2016; 150:591-59 classic form of Barrett's esophagus, also known as long-segment Barrett's esophagus, should be recognized as arbitrary. In fact, a number of in-vestigators recently have described a new entity, the so-called short-segment Barrett's esophagus, in which this columnar epithelium with intesti-nal metaplasia is confined to the distal esopha fore, studied the prevalence of BE and symptom status in older patients referred for colonoscopy. METHODS All patients referred for outpatient colonoscopy were eligible if they were at least 65 yr old and had not previously undergone esophagoscopy. After informed consent, the patients completed detailed GER questionnaires. During the research endoscopy, the endoscopist recorded the. OBJECTIVE. The purpose of this study was to determine the findings of short-segment Barrett's esophagus on double-contrast esophagography. MATERIALS AND METHODS. A review of pathology and endoscopy data revealed 142 patients with short-segment Barrett's esophagus, which was defined as columnar epithelium in the distal esophagus extending 3 cm. Radiology 9 Springer-Verlag 1985 Barrett's Esophagus Complicating Sclcroderma Farooq P. Agha 1 and Lyubica Dabich 2 Departments of 1Radiology and ZInternal Medicine, University of Michigan Hospitals, Ann Arbor, Michigan, USA Abstract. Two patients with scleroderma whose esophageal involvement was associated with long

Barrett's esophagus typically arises in patients with chronic gastroesophageal reflux. Increased acid exposures, decreased lower esophageal sphincter muscle tone, and impaired esophageal acid clearance have all been correlated with the development of this condition. 84 Chronic distal esophageal acid inflammation leads to a variety of cellular changes, including loss of disaccharidase. Free Download Barretts Esophagus PowerPoint Presentation. Minimum of 8 biopsies provides adequate assessment of Intestinal Metaplasia Starting distally 1-2cm above GEJ, 4 quadrant random biopsies should be done every 2cm while advancing proximally Targeted biopsies of visible lesions (should be done before random biopsies) Ideally, erosive esophagitis should be healed prior to biopsies for BE. Barrett esophagus is defined by the conversion of normal esophageal squamous epithelium to metaplastic columnar epithelium. endoscopy, radiology or pathology), and geographical location. For instance, in Japan, the gastroesophageal junction is defined as the lowest extent of the esophageal palisade blood vessels; however, most western. Hypercontracting esophagus (nutcracker esophagus) has normal peristalsis but high manometric intra-esophageal pressures; Barium esophagram will be normal or show dysmotility; Treatment. Proton pump inhibitors, nitroglycerin, calcium channel blockers and botulinum toxin have been used to treat . Corkscrew Esophagus, Diffuse Esophageal Spasm Barrett's esophagus in a teenager with a ringed esophagus. Abstract. Pediatr Radiol (1999) 29: 641 LETTERS TO T H E E DITOR Ó Springer-Verlag 1999 Jose L. Vazquez Carlo Buonomo Samuel Nurko Barrett's esophagus in a teenager with a ringed esophagus Received: 3 November 1998 Accepted: 23 February 1999 Sir, We read with interest the article ªRinged esophagus (feline esophagus) in child- hoodº.

The Radiology Assistant : Esophagus I: anatomy, rings

Barrett's esophagus (columnar metaplasia) is the result of long-standing reflux esophagitis. Most patients have reflux and a hiatus hernia. The diagnosis is strongly suggested by: Mid or high esophageal ulcer Mid or high esophageal web-like stricture Reticular mucosal pattern On the left a patient with a Barrett's esophagus A, Typical Barrett's esophagus as seen on narrow band imaging. Numbers represent the area where endomicroscopy was performed. Numbers represent the area where endomicroscopy was performed. B, Esophageal glands with normal architecture and the presence of goblet cells endoscopically suspected esophageal metaplasia (ESEM) - defined as esophageal epithelium with endoscopic appearance of Barrett esophagus, but without histologic confirmation (Lancet 2009 Mar 7;373(9666):850) long-segment Barrett esophagus - Barrett esophagus > 3 cm in length 1; short-segment Barrett esophagus - Barrett esophagus < 3 cm in length

Esophageal motility is within the limits of normal. The esophagus is structurally normal without intrinsic or extrinsic masses. The esophageal mucosa appears normal. No gastroesophageal reflux was demonstrated during this examination, despite the performance of maneuvers to elicit GE reflux Barrett's esophagus is a well-known risk factor for the development of esophageal adenocarcinoma. Current practice guidelines recommend endoscopic surveillance of patients with Barrett's esophagus in an attempt to detect cancer at an early and potentially curable stage. This review addresses the rationale behind surveillance and criteria for inclusion of patients in surveillance programs as.

Is the radiologic appearance of Barrett&#39;s esophagus

GERD, Barrett's Esophagus, and the Link to Esophageal Cancer April 28, 2021. If you suffer from chronic acid reflux, or GERD - which is acid reflux that occurs at least one to two times per week - you may be at risk for esophageal cancer The Radiology Assistant : Esophagus - Part I. Saved by Chirt Georgiana. Nutcracker Esophagus Esophageal Spasm Reflux Esophagitis Lump In Throat Valsalva Maneuver Hiatus Hernia Signs Of Inflammation Gastroesophageal Reflux Disease Crohns Risk Factors: Adenocarcinoma Associated with Barretts's esophagus, GERD & hiatal hernia. Obesity (3 to 4 fold risk) Smoking (2 to 3 fold risk) Increased esophageal acid exposure such as Zollinger-Ellison syndrome. Barrett's esophagus is ametaplasia of the esophageal epithelial lining

The only contribution of Barrett in this regard is what he wrote in 1960 a lower esophagus lined by columnar epithelium may cause oesophagitis and its complications, and it is the usual source of columnar‐cell carcinoma that arises in the gullet as opposed to the stomach. 69 Tileston in reviewing the published work about peptic ulcers. Barrett's esophagus is when the normal cells that line your food pipe (esophagus) turn into cells not usually found in your body. The new cells take over because the lining of the esophagus has been damaged. The new, abnormal cells are called specialized columnar cells Barrett's Esophagus involves a change in the normal squamous lining of the esophagus to an intestinal type as a response to acid exposure from GERD. Barrett's Esophagus is significant because it carries an elevated risk for esophageal cancer, abut 30-125 times that of the general population

Pathology Outlines - Barrett esophagu

Barrett NR. Chronic peptic ulcer of the oesophagus and 'oesophagitis'. Br J Surg. 1950 Oct. 38(150):175-82.. Allison PR, Johnstone AS. The oesophagus lined with gastric mucous membrane Barrett's is a way the esophagus defends itself: The cells in the lining of the esophagus start to change because they've been exposed to acid for many years. Barrett's esophagus is considered a precancerous lesion and increases the risk for esophageal cancer. Only a small percentage of patients with Barrett's esophagus end up. Pattern Barrett as a Radiologic Sign Esophagus seen on double-contrast studies of the stomach. In either case, the reticular pattern has a distinctive radiologic appearance that usually can be differentiated from mucosal irregularity caused by shallow ulcers, nodules, or plaques. Ironically, however, the Marc S. Levine, M.D. Herbert Y. Kressel, M.D. Igor Laufer, M.D. Hans Herlinger, M.D.

The Radiology Assistant : Esophagus II: Strictures, Acute

The precursor cell from which Barrett esophagus develops has yet to be determined. Proximal migration of columnar cells was proposed to underlie the pathogenesis of Barrett esophagus, but animal models show that Barrett esophagus can develop in the absence of contiguous columnar epithelium The radiologic diagnosis of Barrett's esophagus is limited by lack of criteria that are both sensitive and specific. The major value of double-contrast esophagography is its ability to classify patients into high risk (high stricture, ulcer or reticular pattern), moderate risk (esophagitis and/or distal peptic strictures), and low-risk (absence. Clinical Radiology (1987) 38, 415-418 Imaging Barrett's Oesophagus E. L. KWEKA*, M. O'NEILL, C. COONEY and G. O'SULLIVANt Departments of Radiology and Surgery, Regional Hospital, Wilton, Cork, Ireland Eight patients who had Barrett's oesophagus confirmed by histology are presented A two-part retrospective study was conducted to assess the value of a reticular pattern as a sign of columnar-lined esophagus. Radiographic, endoscopic, and histologic findings were reviewed in 124 patients with known Barrett esophagus; then all barium esophagograms done at our institution during a 3 1/2 month period were reviewed and presence of a reticular pattern was correlated with. Reticular appearing mucosa in the distal esophagus may be seen with reflux esophagitis and Barrett's esophagus. Long segment mid esophageal esophagitis may be seen in patients with recent mediastinal radiation. In contrast, CT findings of esophagitis - regardless of the underlying cause---include a long segment of circumferential esophageal.

esophagus, and these tumors are much more likely to invade the stomach. Pathology key point: Because esophageal adenocarcinomas arise from preexisting Barrett mucosa, these tumors are usually located in the lower third of the thoracic esophagus The classic radiographic appearance is a stricture in the mid esophagus accompanied by a mucosal reticular pattern, although the latter is rarely seen (Figures 4 and 5). 12,13 Other findings, such as a widened hiatus, shortened esophagus, spontaneous reflux, esophagitis, stricture, and a hiatal hernia are often present in Barrett's esophagus. Introduction. Barrett's esophagus (BE) is a well-established risk factor for developing esophageal adenocarcinoma. Endoscopic surveillance programs have been established in order to detect the presence of neoplasia and lesions at potentially curative stages including high grade dysplasia (HGD) and intramucosal carcinoma (IMC) ().The development of new endoscopic therapies, in particular. Barrett's oesophagus (BO) is a common premalignant condition, which carries a risk of progression to oesophageal adenocarcinoma. Recent advances include quantifying the risk of neoplasia progression, novel diagnostic tools and development of new endoscopic techniques to treat early Barrett's cancer Barrett's oesophagus Treatment. Offer long term maintenance full dose PPI (eg omeprazole 20mg daily) Remain on full dose PPI (high dose may be necessary to control symptoms) High dose PPI (eg omeprazole 40mg daily) Switch to another PPI at full or high dose if initial PPI fails to control symptoms. Endoscopic follow up of Barrett's oesophagus.

Barrett Esophagus Elizabeth A. Montgomery, MD Key Facts Terminology Columnar-lined esophagus Change of esophageal mucosa Any length Visibility at endoscopy Contains intestinal metaplasia on biopsy Outside USA: Barrett esophagus is often used for any columnar mucosa found in tubular esophagus In USA: Term restricted to intestinal metaplasia and requires endoscopic correlation Etiology. Barrett´s Esophagus (BE) is a precancerous condition characterized by replacement of normal squamous epithelium in the lower esophagus by specialized glandular epithelium. BE is macroscopically visible as a salmon-red colored mucosa extending into healthy, pale esophageal mucosa Introduction. Barrett's esophagus (BE) is a condition resulting from chronic esophageal injury causing a change in the lining of the esophagus from normal squamous epithelium to a metaplastic columnar epithelium ().The prevalence of BE is estimated to be 1.6% in the general population, and higher in patients with gastroesophageal reflux disease (GERD) (2-4)

Video: Barrett's Esophagus Imaging: Overview, Radiography

Cigarette Smoking and the Risk of Barrett&#39;s EsophagusRadiology of GI Lumen - Gastroenterology 2 with Bruggen at

OESOPHAGUS AND STOMACH EDITORIAL New Barrett's guidelines: an opportunity to improve patient experience and save resources Stephen Attwood Correspondence to Professor Stephen Attwood, Department of Upper Gastrointestinal Surgery, Durham University, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear NE29 8NH, UK; [email protected] Received 11 June 2014 Accepted 16 June. Barrett Esophagus. Published on 18/07/2015 by admin. Filed under Radiology. Last modified 18/07/2015. Print this page. Average : rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star. Your rating: none, Average: 0 (0 votes) Rate it. This article have been viewed 1044 times. Tweet Due to more severe reflux disease. Barrett's esophagus is a precancerous condition. Learn about our expert care, risk factors, and treatments. Radiology, Endocrinology and other specialties at VCU Health to provide the latest technology and a true multidisciplinary view of the problem at hand. This supports greater accuracy in diagnosis and superior therapeutic decisions for. The definition of Barrett's esophagus specifies a lower esophageal location, but it is noteworthy that heterotopic gastric mucosa may also be found in the upper esophagus . Patients with proximal heterotopic gastric mucosa show a basic fundic-type or antral-type gastric mucosa with few variations and no intestinal metaplasia

Barrett's esophagus is caused when the cells in your esophagus (food pipe) change and become like the cells found in your stomach lining. These new, abnormal cells damage your esophageal tissue lining and can lead to esophageal cancer.. You are more likely to develop Barrett's esophagus disease if you've been diagnosed with gastroesophageal reflux disease (GERD), commonly referred to as. ix) Efferent nerves arise from CN V, VII, X, XI, XII and C1-3. x) Motor disorders of pharyngeal swallowing: a) Incomplete upper sphincter relaxation. b) Loss of skeletal portion of cervical esophagus. b) Esophageal phase of swallowing. i) Pressure gradient of -6mm Hg in thoracic esophagus to +6mm Hg intraabdominal Barrett's esophagus is metaplasia of the normal squamous epithelium of the esophagus to columnar epithelium. Estimated prevalence of Barrett's in the general population is 5%, and the majority have do not have dysplasia, but if there is high grade dysplasia, there is a 7% annual risk of developing adenocarcinoma, which is what we ultimately. Abstract. Barium esophagography is an invaluable radiologic technique for detecting a host of morphologic abnormalities in the esophagus. Double-contrast barium studies are particularly well suited for diagnosing reflux esophagitis and its complications, including peptic strictures and Barrett's esophagus

Cytosponge Finds More Barrett&#39;s Esophagus in Primary-CareThe Radiology Assistant : Esophagus I: anatomy, rings

Barrett's Esophagus Presentation A 55-year-old white man presents to your office having been referred by a gastroenterologist. The patient has a long-standing history of acid reflux symptoms. He was diagnosed with Barrett's esophagus 5 years before his clinic visit and had undergone periodic endoscopic surveillance. He was not taking any acid suppression medications because hi The definition of Barrett esophagus (and the gastroesophageal junction) varies worldwide. In the uK and Japan, goblet cells are not required for a diagnosis of Barrett esophagus, whereas in all other countries, they are. Goblet cells, and dysplasia even more so, are morphological biomarkers of cancer risk in patients with Barrett esophagus, but. Radiofrequency Ablation of Barrett's Esophagus Shajan Peter C. Mel Wilcox Klaus Mönkemüller DEFINITION Barrett's esophagus (BE) is an acquired condition due to a change in the normal esophageal squamous epithelium to columnar epithelium containing goblet cells. This metaplastic change can progress to low-grade dysplasia (LGD) and high-grade dysplasia (HGD), with the latter having a 5 There are 800,000 Canadians living with Barrett's Esophagus In Canada, approximately 400,000 people with Barrett's are asymptomatic Diagnosis of Barrett's esophagus requires that suspected patients undergo endoscopy and biopsy. For the current cases of this disease, diagnosis costs more than $400 million Abstract Barrett's esophagus is a condition in which normal stratified squamous epithelium of the esophagus is replaced with columnar epithelium. It is the primary precursor lesion for esophageal adenocarcinoma and is thought to progress in a stepwise manner from metaplasia through increasing grades of dysplasia to adenocarcinoma. Diagnosis requires the combination of endoscopic evaluation.